I first came across emacsspeak several years ago and was reminded of it over the weekend when a piece of rock hit me in the eye while out climbing. Luckily no real harm was done and I escaped with just a scratch. As the name suggests it is based on emacs but it doesn't just speech-enable emacs. There are currently 150 applications supported allowing the visually impaired to do anything from using google maps to programming in java and ruby.
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